hyperalgesia 통증


Hyperalgesia is a medical condition characterized by an increased sensitivity to pain stimuli. Unlike normal pain response, where the sensation is proportional to the intensity of the stimulus, hyperalgesia amplifies pain perception. This blog post aims to provide a detailed overview of hyperalgesia, including its causes, symptoms, diagnosis, and possible management strategies.

Types of Hyperalgesia

Primary Hyperalgesia

Primary hyperalgesia occurs when there is a heightened response to painful stimuli at the site of injury or inflammation. This form of hyperalgesia is commonly observed in patients with inflammatory conditions such as arthritis or tissue damage.

Secondary Hyperalgesia

Secondary hyperalgesia refers to increased pain sensitivity in areas surrounding the site of injury or inflammation. The non-injured tissues become more sensitive to painful stimuli, resulting in a larger area of pain perception. This type of hyperalgesia is often associated with central sensitization, a phenomenon involving changes in the central nervous system.

Diffuse Noxious Inhibitory Control (DNIC) Dysfunction

DNIC dysfunction is a form of hyperalgesia in which the body’s natural pain inhibitory pathways fail to function properly. These pathways are responsible for modulating pain signals and reducing pain perception. When DNIC dysfunction occurs, it can lead to an amplification of pain responses and increased sensitivity to noxious stimuli.

Causes and Risk Factors

Hyperalgesia can have various underlying causes and risk factors, including:

  • Chronic pain conditions such as fibromyalgia or neuropathy
  • Inflammatory disorders like rheumatoid arthritis
  • Nerve damage or neuropathies
  • Surgical procedures
  • Long-term use of opioid medications
  • Psychological factors such as anxiety and depression

Diagnosing Hyperalgesia

Diagnosing hyperalgesia involves a comprehensive evaluation of the patient’s medical history, physical examination, and assessment of pain sensitivity. Healthcare professionals may use quantitative sensory testing and other diagnostic tools to determine the extent of hyperalgesia and rule out other possible conditions.

Managing Hyperalgesia

The management of hyperalgesia often involves a multimodal approach, combining pharmacological, physical, and psychological interventions. Some common strategies include:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) to reduce inflammation and pain
  • Nerve blocks or steroid injections to alleviate localized pain
  • Physical therapy techniques such as stretching, massage, and exercises
  • Cognitive-behavioral therapy (CBT) to address psychological factors contributing to pain sensitivity
  • Neuromodulation techniques like transcutaneous electrical nerve stimulation (TENS) or spinal cord stimulation


Hyperalgesia is a complex condition that requires comprehensive assessment and a holistic treatment approach. By understanding the different types of hyperalgesia, identifying the underlying causes, and implementing appropriate management strategies, individuals with hyperalgesia can experience improved pain control and quality of life. If you suspect you may have hyperalgesia, consult with a healthcare professional for a proper diagnosis and personalized treatment plan.